TRANSDERMAL DRUG DELIVERY SYSTEM IN ADVANCED TECHNOLOGY

Abstract

Overview of transdermal drug delivery (TDDS), its advantages, challenges, and recent advanced technologies such as microneedles, nanoparticles, iontophoresis, and smart patches. The transdermal drug delivery systems, also known as TDDS, are the most effective alternative to the oral and parenteral routes to deliver therapeutic molecules across the skin in order to produce systemic effects. TDDS possess several benefits such as self-administrable nature, escape of first-pass metabolism, minimize dose, less side effects, better dosage regimen, termination of dosing at any time, absence of gastric irritation, and improved patient compliance. In the earlier scenario, TDDS was indicated only for the transdermal patches. These patches include matrix devices, reservoir type, micro-reservoir forms, and adhesive controlled systems. In the present situation, various state of the art technologies were introduced in advancing TDDS utilization. For passive drug delivery, nanovesicles, polymeric nanocarriers adhesive-controlled and nanoemulsions were implemented.